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90 tablets capsules every 90 days Limit also includes all Proton Pump Inhibitors Aciphex, Prevacid, Prilosec, Proronix ; 2 vials every 30 days 1800 ml every 90 days 3 rings every 84 days 120 tablets every 30 days 120 tablets every 30 days 18 ml 3 bottles of 6 ml ; every 90 days 120 capsules every 30 days Limit also includes MS Contin 10 patches every 90 days 2 vials every 30 days 180 tablets capsules every 30 days 600 ml every 30 days 120 tablets every 30 days 30 ml every 30 days Limit also includes Oxyfast solution 30 ml every 30 days Limit also includes Oxydose solution 26 patches every 90 days 15 ml 3 bottles of 5 ml or 6 bottles of 2.5 ml ; every 90 days 12 injections every 84 days 12 injections every 84 days 240 tablets every 30 days 360 ml every 90 days 3 vials every 84 days 90 tablets every 90 days 2 vials every 30 days 90 tablets capsules every 90 days Limit also includes all Proton Pump Inhibitors Aciphex, Nexium, Prilosec, Lrotonix ; 14 packs 1 pack contains 8 tablets ; every 30 days 104 tablets every 90 days 90 tablets capsules every 90 days Limit also includes all Proton Pump Inhibitors Aciphex, Nexium, Prevacid, Prptonix ; except generic Prilosec omeprazole ; 20 mg 36 injections every 84 days 18 injections every 84 days 90 tablets capsules packets every 90 days Limit also includes all Proton Pump Inhibitors Aciphex, Nexium, Prevacid, Prilosec. TABLE 3. HISTOLOGIC CHARACTERISTICS AND SIZE OF THE MOST ADVANCED PROXIMAL NEOPLASM FOUND AT COLONOSCOPY IN 203 ASYMPTOMATIC AVERAGE-RISK PATIENTS WITH BENIGN RECTOSIGMOID ADENOMAS, ACCORDING TO THE SIZE OF THE INDEX LESIONS!


NDA 20-988 S-024 Page 16 Two Minute Infusion PROTONIX I.V. for Injection should be reconstituted with IO ml of 0.9% Sodium Chloride Injection, USP, to a final concentration of approximately 4 mg ml. The reconstituted solution may be stored for up to 2 hours at room temperature prior to intravenous infusion and does not need to be protected from light. PROTONIX I.V. for Injection should be administered intravenously over a period of at least 2 minutes. And through the patient's pharyngeal secretions or urine. Infection can also spread from person to person by sexual contact. 6. Incubation period--Commonly 6 21 days. 7. Period of communicability--Person-to-person spread may theoretically occur during the acute febrile phase when virus is present in the throat. Virus may be excreted in urine of patients for 39 weeks from onset of illness. 8. Susceptibility--All ages are susceptible; the duration of immunity following infection is unknown. 9. Methods of control -- A. Preventive measures: Specific rodent control. B. Control of patient, contacts and the immediate environment: 1 ; Report to local health authority: Individual cases should be reported, Class 2 see Reporting ; . 2 ; Isolation: Institute immediate strict isolation in a private hospital room away from traffic patterns. Entry of nonessential staff and visitors should be restricted. Nosocomial transmission has occurred, and strict procedures for isolation of body fluids and excreta must be maintained. Recourse to a negative pressure room and respiratory protection is desirable, if possible. Male patients should refrain from unprotected sexual activity until the semen has been shown to be free of virus or for 3 months. To reduce infectious exposure, laboratory tests should be kept to the minimum necessary for proper diagnosis and patient care, and only performed where full infection control measures are correctly implemented. Technicians must be alerted to the nature of the specimens and supervised to ensure application of appropriate specimen inactivation isolation procedures. Dead bodies should be sealed in leakproof material and cremated or buried promptly in a sealed casket. 3 ; Concurrent disinfection: Patient's excreta, sputum, blood and all objects with which the patient has had contact, including laboratory equipment used to carry out tests on blood, must be disinfected with 0.5% sodium hypochlorite solution or 0.5% phenol with detergent, and, as far as possible, effective heating methods, such as autoclaving, incineration, boiling or irradiation, as appropriate. Laboratory testing must be carried out in special high containment facilities; if there is no such facility, tests should be kept to a minimum and specimens handled by experienced techni.

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In experiment I, the threshold depth for detecting a spectral notch centered at 8 kHz in an otherwise flat-spectrum noise was measured as a function of the noise spectrum level. Threshold depths increased gradually with spectrum level. This result is explained in terms of the broadening of cochlear filters with level and of the narrow dynamic range of most auditory nerve AN ; fibers. Experiment II investigated the extent that notch detection is affected by stimulus duration. On average, threshold depths were larger for shorter 25-ms ; than for longer 220-ms ; stimuli, particularly at higher sensation levels. This suggests that the adapted AN response is important for encoding spectral information, despite the fact that spectral features may be more clearly encoded at the onset, where AN fibers have a wider dynamic range. In experiment III, the steady spectral notch was replaced by a dynamic one whose center frequency changed abruptly after 110 ms from 7 to 9 kHz. Depths in this condition improved at high levels. Therefore, transient spectral information is more easily detected at high levels, which relates to the wide dynamic range of AN fibers for sudden increases in level. [Work supported by FIS PI020343, G03 203, and MCYT]. 3. Does the patient have contraindications to Aciphex, Protonis pantoprazole ; or generic omeprazole? . YES NO If yes, please describe which agent s ; and what the contraindications are 4. Are there other clinical considerations that would require a non-formulary PPI agent? Please include any additional clinical information that should be considered for this review and zantac.

Experience, patients do very well with it, " he adds. Indeed, the pivotal clinical trial that led to the approval of Protoniix showed that, over a 12-month period, use of the product completely eliminated all heartburn symptoms for 93 percent of the nights studied. Dr. Peikin also administers Protonix intravenously in hospital settings. In fact, Protonix I.V. has been used for more than 5 million patients over the course of the past seven years. Dr. Peikin is very enthusiastic about Protonix use for GERD. "My patients say Protonix is a very valuable drug. It's a therapy that means so much to a patient's quality of life. Index of Drugs PREMPHASE -25 prenatabs prenatal U prenatal prenatal mr 90 fe 35 prenatal mtr selenium 35 prenatal prenatal rx 1 PREVIFEM PREZISTA PRIMAXIN 3 PRIMAXIN I.V. - 3 primidone 5 probenecid 7 procainamide hcl 16 PROCALAMINE -35 prochlorperazine edisylate injection 7, 11 prochlorperazine maleate 7, 11 PROCRIT PROCTOCARE-HC --20 PROCTOCORT -20 proctocream-hc --20 PROCTOFOAM-HC --20 proctosol-hc PROGRAF promethazine hcl -- 7, 31 promethazine vc syrup --31 propafenone hcl -16 propantheline bromide --21 propoxyphene hcl 2 propoxyphene hcl w apap -- 2 propoxyphene napsylate w apap -- 2 propranolol hcl -- 8, 16 PROTONIX PROTONIX IV 22 PROVIGIL PRUDOXIN PURINETHOL - 9 pyrazinamide 9 pyridostigmine bromide 13 Q 18 quinaretic 18 quinidine gluconate -- 16 quinidine sulfate 10 quinine 10 QVAR 32 R RABAVERT 28 17 ranitidine hcl tablets -- 22 RAPAMUNE -- 28 5 RAZADYNE ER 5 RECLIPSEN -- 25 RECOMBIVAX HB 28 REGRANEX -- 21 RELENZA 13 REMICADE 28 RENAMIN 35 REQUIP 11 RESCRIPTOR -- 12 reserpine 15 RESTASIS 29 RETROVIR 12 RETROVIR IV 12 REVATIO 32 REYATAZ 13 ribavirin 13 RIDAURA 29 rifampin 9 RILUTEK 19 rimantadine hcl -- 13 RISPERDAL CONSTA - 11 RISPERDAL M-TABS -- 11 RISPERDAL SUSPENSION 11 RISPERDAL TABLETS 11 ROCEPHIN 3 ROFERON-A - 29 roxicodone 2 and carafate.

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I'd take half as much protonix everyday but the pills are an odd shape and supposedly horrible. This review did not include PPI use for simple heartburn. It did not include fixed combinations of PPIs with other drugs. omeprazole esomeprazole Prilosec ; Nexium ; lansoprazole pantoprazole rabeprazole Prevacid ; Protonix ; Aciphex and metoclopramide.

Discounting of Protonix IV drives uptake of oral Protonix. Large purchasers are offered IV and oral Protonix as a `bundle': deep discounts are offered if purchasers buy both formulations and commit to high levels of use of oral Protonix. Sales of Protonix IV are small, but the formulation's value to the brand is in driving uptake of oral Protonix. In the US, Protonix enjoys the best health insurance formulary status of any branded prescription PPI. Protonix's favorable formulary status is driven by deep discounting to volume purchasers. Research shows that increases in patient copays for PPIs lead to reductions in use of 17-33%, making favorable formulary status crucial. Despite the availability of OTC and generic omeprazole, AstraZeneca's GI franchise remains strong. Prilosec sales continued to fall in 2003, but Nexium was the market share winner, rather than generic and OTC competitors. Meanwhile, competitor PPIs are using reformulations and patent defense strategies to extend product lifecycles.

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Buy protonix from canada drug superstore, save with free shipping purchase viagra drugs harrisburg local affordable pharmacist and allopurinol. Abatacept Orencia ; Alglucoside Alfa Myozyme ; Allopurinol Sodium Ascorbic Acid Vitamin C ; Arginine Hydrochloride Ascorbic Acid Atropine Sulfate Edrophonium Chloride Aztreonam Bumetanide Bupivacaine, 0.25% Bupivacaine, 0.50% Bupivacaine, 0.75% Calcium Chloride Cefotetan Cimetidine HCl Tagamet ; Clavulanate Potassium Ticarcillin Disodium Clindamycin Phosphate Cleocin ; Copper Sulfate Decitabine DacogenTM ; Dextrose 5%-0.45% NaCl D5 1 2 solution ; Dextrose 50% Diltiazem Hydrochloride Doxycycline Hyclate Edrophonium Chloride Enalaprilat Vasotec ; Esmolol Hydrochloride Etomidate Amidate ; Famotidine Flumazenil Folic Acid Galsulfase Naglazyme ; Glycopyrrolate Hetastarch NaCl 6 GM 100 ml 0.9% Ibandronate Sodium Boniva ; Ketamine Hcl Labetalol Hcl Lidocaine Methohexital Sodium Brevital Sodium ; Metoprolol Tartrate Lopressor ; Metronidazole In Nacl Flagyl ; Micafungin Sodium Mycamine ; Morrhuate Sodium Nafcillin Sodium Naltrexone Vivitrol ; Nitroglycerin Panitumumab VectibixTM ; Peginterferon alfa-2a Pegasys ; Potassium Acetate Potassium phosphate Propofol Protonix Ranibizumab injection LucentisTM ; Rifampin Sarracenia Purpura Sodium Acetate Sodium Bicarbonate, 8.4% Sodium Chloride 0.45% 1 2 NS IV solution ; Sodium Chloride 0.45% 1 2 NS IV solution ; Sodium Chloride 0.45% 1 2 NS IV solution ; Sodium Chloride 0.9% NS IV solution ; Sodium Chloride, Hypertonic Sodium Hyaluronate, For Intra-Articular Injection Orthovisc ; Sodium Tetradecyl Sulfate Sotradecol ; 1% Sodium thiosulfate Date Printed: 4 2007 PM. He August 23, 1995 issue of JAMA contained the data from the Puget Sound HMO's survey of drug use and myocardial infarction Psaty et al. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995; 274: 620-625 ; . After the oral presentation of the data at the March 8 meeting of the Council for Cardiovascular Epidemiology, the media coverage was so one-sided and sensational, with headlines like Blood Pressure Drug Causes Heart Attack that even Dr. Psaty described the coverage as "a public health hazard." This time the coverage was not as extensive and, instead of front-page scary headlines, the data were more reasonably presented along with the message from the accompanying JAMA editorial by Buring et al. Their message was clearly stated in the subtitle of their editorial: "A hypothesis formulated but not yet tested." Buring pointed out the major limitation of this and all case-control studies. "The fact is that, in this design, primary healthcare providers selected particular patients for a given antihypertensive drug regimen. This self-selection is likely to have introduced at least modest biases into the results because of differences between those who were prescribed calcium channel blockers and those who were prescribed other antihypertensive medications." Buring could have recalled the major scare of the 1970s over the claim that reserpine then a very popular antihypertensive drug ; caused breast cancer, based on case-control studies. This claim was subsequently shown to be absolutely wrong because--would you believe--it was based on "the biases of differences between those who were prescribed [reserpine] and those who were prescribed other antihypertensive medications." So, let us remember the closing comments by Buring. "It would be particularly tragic if the large benefits of antihypertensive drug therapy are lost as a result of stopping medication because of an as yet unsubstantiated fear of an increased risk of myocardial infarction." At the same time, Psaty's final comments seem sensible and worth repeating. "Ongoing large-scale clinical trials will assess the effect of various antihypertensive therapies, including calcium channel blockers, on several important cardiovascular outcomes. Until these results are available, the findings of this study support the current guidelines from the JNC, which recommend diuretics and -blockers as first-line agents unless they are contraindicated, unacceptable, or not tolerated and ranitidine.
Lord Krishna says in His Gita: "Tasmat sarveshu kaleshu mam anusmara yudhyacha--Therefore, at all times think of Me and fight." Give the mind to God and the hand to work. The typist works at the machine and talks with his friends. The player on the harmonium plays on the organ and talks and jokes with his friends; the lady knits and talks with her comrades. The mind of the girl who has a water pot on her head is on the water pot, though she is talking and joking with her companions while she is walking on the road. A nurse while she is nursing the baby of another lady has her mind rivetted on her own baby. A cowherd while he is looking after the cows of other people has his mind fixed on his own cow. Even so, have your mind fixed at the lotus feet of the Lord, while you are doing your household duties and office work. You will realise Self-consciousness quickly. Just as the water remains unaffected in the lotus leaf, just as the oil floats upon the surface of the water without being affected in any way, so also you should remain in the world amidst pleasures and difficulties. Just as the tongue is not affected by taking ghee, so also you should remain unaffected even amidst worldly activities and troubles. You must keep up the Nirlipta state. This is Jnana. This is balance Samata ; . You may fail to keep the balance and Nirlipta state a thousand and one times. But in the long run you are bound to succeed if you persist in your practice and if you discipline the mind properly. Every failure is a pillar for future success. Remember this point well. A Karma Yogin should not expect even return of love, appreciation, gratitude, admiration from the people whom he is serving. Sales of protonix r ; pantoprazole sodium ; , wyeth’ s branded proton pump inhibitor indicated for gastroesophageal reflux disease, continued to be adversely affected during the 2008 second quarter and first half by the at risk launch of generic pantoprazole tablets in the united states by teva pharmaceuticals usa, inc teva ; and sun pharmaceutical industries, ltd sun and prevacid. Figure 4.- Upper Injection Technique. Lower Injection Technique 1. Remove yellow needle cap. 2. Place thumb in deepest portion of coronoid notch. Refer to Figure 5. 3. Insert needle at point where seam between cheek and throat turns upward toward maxilla. 4. Barrel of Dental Syringe is kept over teeth 3 and 4 on opposite side of injection. Insert needle until bone is contacted, withdraw slightly only 5 to 10 needle is left exposed ; , then inject entire contents of Dental Carpule. Infiltrate or inject soft tissue area surrounding nerve. Avoid injecting nerve directly i.e., injecting against resistance. Several of our strategic initiatives involve alliances with other companies, including our collaborations with: • amgen on enbrel ; • altana on protonix ; • king pharmaceuticals on altace ; • johnson & johnson under which we supply sirolimus, the active ingredient in rapamune , to coat the cypher stent; and • medtronic sofamor danek, inc on rhbmp-2 and zyloprim. Mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. Toxicol Appl Pharmacol, 125 1 ; : 1-6.
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Do not take the following medicines with REYATAZ atazanavir sulfate ; because they may lower the amount of REYATAZ in your blood. This may lead to an increased HIV viral load. Resistance to REYATAZ or cross-resistance to other HIV medicines may develop: Rifampin also known as Rimactane, Rifadin, Rifater, or Rifamate, used for tuberculosis ; . St. John's wort Hypericum perforatum ; , an herbal product sold as a dietary supplement, or products containing St. John's wort. "Proton-pump inhibitors" used for indigestion, heartburn, or ulcers such as AcipHex rabeprazole ; , Nexium esomeprazole ; , Prevacid lansoprazole ; , Prilosec omeprazole ; , or Protonix pantoprazole ; . The following medicines may require your healthcare provider to monitor your therapy more closely: Viagra sildenafil ; . REYATAZ may increase the chances of serious side effects that can happen with Viagra. Do not use Viagra while you are taking REYATAZ atazanavir sulfate ; , unless your healthcare provider tells you it is okay. Lipitor atorvastatin ; . There is an increased chance of serious side effects if you take REYATAZ with this cholesterol-lowering medicine. Medicines for abnormal heart rhythm: Cordarone amiodarone ; , lidocaine, quinidine also known as Cardioquin, Quinidex, and others ; . Coumadin warfarin ; . Tricyclic antidepressants such as Elavil amitriptyline ; , Norpramin desipramine ; , Sinequan doxepin ; , Surmontil trimipramine ; , Tofranil imipramine ; , or Vivactil protriptyline ; . Medicines to prevent organ transplant rejection: Sandimmune or Neoral cyclosporine ; , Rapamune sirolimus ; , or Prograf tacrolimus ; . The following medicines may require a change in the dose or dose schedule of either REYATAZ or the other medicine: Sustiva efavirenz ; . Fortovase, Invirase saquinavir ; . Norvir ritonavir ; . Mycobutin rifabutin ; . Calcium channel blockers such as Cardizem or Tiazac diltiazem ; , Covera-HS or Isoptin SR verapamil ; and others. Biaxin clarithromycin ; . oral contraceptives "the pill" ; . Videx didanosine ; or antacids. Medicines for indigestion, heartburn, or ulcers such as Axid nizatidine ; , Pepcid AC famotidine ; , Tagamet cimetidine ; , or Zantac ranitidine ; . Remember: 1. Know all the medicines you take. 2. Tell your healthcare provider about all the medicines you take. 3. Do not start a new medicine without talking to your healthcare provider. How should I store REYATAZ? Store REYATAZ Capsules at room temperature, 59 to 86 F not store this medicine in a damp place such as a bathroom medicine cabinet or near the kitchen sink. Keep your medicine in a tightly closed container. Throw away REYATAZ when it is outdated or no longer needed by flushing it down the toilet or pouring it down the sink. General information about REYATAZ This medicine was prescribed for your particular condition. Do not use REYATAZ for another condition. Do not give REYATAZ to other people, even if they have the same symptoms you have. It may harm them. Keep REYATAZ and all medicines out of the reach of children and pets. This summary does not include everything there is to know about REYATAZ. Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Remember, no written summary can replace careful discussion with your healthcare provider. If you would like more information, talk with your healthcare provider or you can call 1-800-426-7644. What are the ingredients in REYATAZ? Active Ingredient: atazanavir sulfate Inactive Ingredients: Crospovidone, lactose monohydrate milk sugar ; , magnesium stearate, gelatin, FD&C Blue #2, and titanium dioxide. * Videx is a registered trademark of Bristol-Myers Squibb Company. Coumadin and Sustiva are registered trademarks of Bristol-Myers Squibb Pharma Company. Other brands listed are the trademarks of their respective owners and are not trademarks of Bristol-Myers Squibb Company. This Patient Information Leaflet has been approved by the U.S. Food and Drug Administration.
It is estimated that 60, 000 new cases of Parkinson's disease are diagnosed each year, adding to the estimated one to 1.5 million Americans who currently have the disease. There were nearly 17, 000 Parkinson's disease-related deaths in 2002. While the condition usually develops after the age of 55, the disease may affect people in their 30s and 40s. Parkinson's disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine and prednisolone. Weeks post-infection a, b, c: Values within a block followed by different letters are significantly different p 0.05 ; . * Bursal weight: relative bursal weight bursal weight body weight ; X 1000 * Stimulation index [ cpm of unstimulated ; ] ND: not done. 35% functional capacity ; , and gastroesophageal reflux disease. Her medications include advair inhaler 0 month ; , albuterol, diltiazam 180 mg qd, hydrochlorothiazide 25 mg qd, spironolactone 100 mg qd, diphenhydramine 25 mg, protonix 2 month ; , and Zantac. About a year ago, Kathy, involved in a 20-year relationship with a man who had emotionally and mentally abused her, first attempted suicide, which led to a long hospital stay. When social workers were unable to find her a shelter, she returned to the same environment. During the next four months, things got worse and she attempted suicide a second time. She was hospitalized for two weeks. She was then placed in the women's transitional housing facility. Kathy's lifestyle has changed dramatically. She must ration food stamps and the food basket and thus eats more vegetables and less meat. Because she uses public transportation, she has increased her exercise level by walking to and from the bus stops. She has lost 53 pounds since last July. Her weight loss has been a great help to her physical and mental health. Kathy has now been seeing the same physician for four months and has developed a relationship. She receives financial aid for her mental health medications. However, these resources were not enough to cover everything on her medication list. She has considered stopping Advair and Protonix.

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Some Blue Cross and Blue Shield of Nebraska members are not eligible to participate in this offer: 1 ; customers covered under a Medicare Supplemental, Medicare Part D Medicare Blue Rx ; or Medicare PPO plan; 2 ; Comprehensive Health Insurance Pool CHIP ; members; 3 ; Federal Employee Program members; 4 ; employees of groups that do not use Blue Cross and Blue Shield of Nebraska's pharmacy benefit pharmacy benefits are provided by another carrier 5 ; customers covered under plans that offer Rx discounts but no coverage for prescription drugs. * If your plan's prescription drug benefits are subject to a deductible, that deductible must be satisfied first before the free generics offer will be available. * Total cost based on Average Wholesale Price or Maximum Allowable Cost, plus an average dispensing fee. Nexium and Crestor are registered trademarks of AstraZeneca. Prevacid is a registered trademark of TAP Pharmaceutical Products Inc. Aciphex is a registered trademark of Eisai Co., Ltd. Protonix is a registered trademark of Wyeth Pharmaceuticals Inc. Prilosec is a registered trademark of Protor & Gamble. Lipitor is a registered trademark of Pfizer, Inc. Vytorin is a registered trademark of MSP Singapore Company, LLC. Zocor is a registered trademark of Merck & Co. Ambien CR is a trademark of sanofi-aventis U.S. LLC. Lunesta is a registered trademark of Sepracor, Inc., Zegerid is a registered trademark of Santarus, Inc. This represents an amendment to your Schedule of Benefits as it relates to your generic drug copay coinsurance for the time period January 1 through March 31, 2008.
A : Okay, next question. Operator: Our next question is from Tim Anderson with Prudential Securities. Please go ahead. Q Timothy Anderson : Thank you. A couple of questions. Can you kind of give us an update how you plan to defend Effexor versus Cymbalta apart from adding more reps, what are going to be the key differentiating points in favor of Effexor in terms of product profile as you see everything shaping up today and then on Protonix, is the rebating and discounting just to clarify that is fully reflected in the sales this quarter and do you expect any further increase in rebates or discounts in the future or are we pretty much done with that revision? A : Okay, Tim, before I turn it over to Bernard let me just say that obviously, you know, we have marketing plans and we have a way that we consider that we should market our products and defend against competitors and we're not going to be all that forthcoming yet because, first of all, Cymbalta is not even on the market and we don't know when it's going to be on the market, we don't even know what the exact profile of the product is going to be so we're limited in how we're going to answer that question but if Bernard would like to make a general comment and then answer your second question, I would turn it over to him. A Bernard Poussot : Okay, on the Cymbalta front we have been waiting for Cymbalta now for a while, and the points are that, we have seen the studies published largely at BID dosage and, you know, Effexor in contrast offers very good efficacy and safety in depression at once a day so we're very encouraged by that. We are ready. I mean we have, you know, prepared for this introduction and we are confident that we can continue to sustain a growth higher than the market going forward. On Protonix for the rebates, my answer is that the quarter reflects, you know, both our volume development and our rebates and, as I said, you know, they are obviously complementary to each other but these are the numbers I mentioned earlier. w w w Cal l Street. co m 212. 931. 6 Copyri ght 2004 Cal l St reet 10 and buy bentyl. At the beginning of the year, in anticipation of new competition in this category we re-assigned 1000 primary care representatives to the Effexor selling effort and in May, so they began to copromote Effexor to psychiatrists to increase our combined specialty sales force to more than 400. Our international performance with Effexor is strong with sales of 27% in the quarter year-overyear. Milestone performance for the Effexor family continues to accumulate. Effexor was launched in 1994 and on its tenth anniversary, has treated more than 10 million patients and hit the milestone of billion cumulative sales. Late last year, Effexor became the number one selling anti-depressant in international markets. We remain on track to exceed this year's target of billion in global sales. Next, let me turn to Protonix. Protonix continues its performance as the fastest growing branded product in the PPI category. Sales were up a strong 25% to 9 million in the quarter. Script growth remained strong at plus 26% in total script volume in the last four weeks of the quarter compared to last year. Allowing Protonix to reach nearly a 22% total prescription share in the PPI category. Our IV form of Protonix was improved this quarter with a launch of a new formulation, which has eliminated the need for an inline filter; an important improvement for hospital users. Protonix IV has just become the number one IV acid suppressant in hospital markets and Protonix tablets has been the number one prescribed oral PPI in hospitals for nearly two years. Performance from Enbrel in the second quarter was outstanding. And while Amgen will report sales in the North American market tomorrow, Wyeth International sales of Enbrel continue to show excellent growth reaching 6 million in the second quarter, an increase of 142% over last year. At 1 million of Enbrel sales for the first half of 2004, we have essentially achieve last year's full year sales of 299 million in the first half alone. Recent news for Enbrel include the US approval for psoriasis. In Europe the application is under active review but the US approval and launch have added new momentum to Enbrel. New and total prescription volume in dermatology for the second quarter were up 31% and 35% respectively over the first quarter. w w w Cal l Street. co m 212. 931. 6 Copyri ght 2004 Cal l St reet 5. NDA 20-988 S-024 Page 7 During 6 days of repeated administration of PROTONIX I.V. for Injection in patients with ZollingerEllison Syndrome, consistent changes of serum gastrin concentrations from baseline were not observed.

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